I have plenty of memory available on my computer; however, I updated to the newest version and now it will not run more than 20 images before forcing me to quit the program. I don’t mind the new changes, but the fact that I cannot run the program as I had been (and I definitely cannot do any other work while the program is running) is causing severe time issues with my work flow. 
I’ve reviewed all Mac settings - no storage issues - just when using Topaz. Help :))))
Please follow the instructions below to perform a clean install to better troubleshoot why you had this problem with Topaz Photo AI:
Start by clearing any previous plist files that are on your computer for Topaz Photo AI by following the steps in the link below:
Topaz Photo AI | plist Files Mac
After you have done this, disable any antivirus, firewall, VPN, or proxy software that might be active on your computer. These tools are sometimes known to interfere with the installer’s ability to download the model files.
Please also ensure that the Topaz Photo AI installer has all the proper settings in your system by going to your Mac System Settings > Privacy & Security tab and scrolling down to the security section. You will want to make sure you have 'App Store and identified developers ’ selected. Here is a video example:
Example of Proper System Preferences
Finally, rerun the installer. You can download a new installer from the downloads page directly :
Let me know how that goes for you and I’ll keep an eye out for your reply.
