Nice Picture. The Dog is cute. 
I love Topaz Denoise AI too, however I always find difficult to remove “low frequency color noise” in High ISO RAW image. 
I tried to adjust the remove color noise slider but it won’t remove “low frequency color noise” unless I move the slider to extremely high value and it remove all color include the subject. 
May be I did something wrong. Hope someone can help me solve the problem. Thanks
Here is the original RAW file from Dpreview.
https://www.dpreview.com/reviews/image-comparison/download-image?s3Key=2bcee69d7ab34431bb28120b502fc950.arw
As comparison, I have tried to process the same raw image in the newest DXO with DeepPRIME AI and here is the result.
