Best settings for saving for print and online?

Hi everyone, I am new here and somewhat to Topaz. I am using a MAC tower with high sierra. It works well and have an older version of Topaz Denoise. I want to create a printable of an image and save it to TIFF in Denoise but what setting would be best for an excellent print I plan to sell? I see Compression which I know should be None, 8 or 16 bit? Save directory Source or Custom? Color profile (Which one)
preserve source, prophoto RGB, srgb, Adobe RGB, Apple, Wide Gamut? and what best options for onine? I’ll just get confused if it’s a scientific explanation. Thank you.