Workflow for 50 year old slides

I have slides which my dad took in the 1950s-1970s.
I’ve scanned many, and performed adjustments over the past 17 years on some of them.

I think there are sometimes multiple problems, which need more than one solution.

  1. Poorly focused original
  2. Motion of a person within an otherwise still scene
  3. Softening of images, perhaps due to chemical deterioration

I see how to mask within Sharpen AI. I suppose I could apply some changes generally, save the file. Start again with a different mask and apply different settings. Maybe go for a third cycle with still other masking and settings applied. Then use an editor which can pull in images as layers, and merge them.

Is that what other folks recommend?