to be fair, as of now, we don’t have much settings to go. You can choose what preset (Gaia-HQ ,Gaia-CG, and the Artemis flavours, but artemis still looks like garbage for most cases) it will use and that’s pretty much it. I had to rollback from 1.2 to 1.1 (1.2 was taking way too long to encode), but in 1.2 using 100% or 200% in resource priority wouldn’t change anything, and anything more than that would result in either the same or crashes.
If one thing can be said, though, is that some users have better final results if first only using the 100% denoise/deblock and then upscaling, but that can take up to double the time compared to if you only upscale, more like using a second-pass while encoding video, so you should think what’s better.
What preset you use (Gaia or Artemis) probably depends on what your source material is, so there’s not a ‘recommended setting’. But I always use HQ (now Gaia-HQ) as it’s the one with better results by my judgement and using my videos, it can be different with your videos and taste. Also, depending on the resolution of the source and your taget resolution, MAYBE it is best to do the upscaling in steps, like from 480p to 1080p, then 4k (if you want to upscale SD material to UHD). If I’m correct it works best like that when using gigapixel, and the algorythm should be the same for VEAI. Haven’t look too much into that, though, as I always use 200x (either 720p to 1440p or 1080p to 4k).
EDIT: just remembered that it seems VEAI is dropping frames, so if you encode more than 1 time it is possible that your final encode would be out of sync, but I believe that can be worked out with mkvmerge