Start with the sharpening Model Strength preference set to Normal.
Open an image. TPAI will choose certain values for Strength and Minor Denoise in the sharpening panel.
Go into Preferences and change the sharpening Model Strength to some other value, e.g. Strong.
TPAI will seemingly re-run Autopilot, yet the Strength and Minor Denoise sliders will not change.
But if you close TPAI and re-run it with that new preference set, then new values for Strength and Minor Denoise will indeed be computed.
Topaz Photo AI v2.1.1 on Windows