Sharpening images with Smooth Trans Focus lenses

Is anyone aware of any problems or special considerations to observe when using Photo AI or any Topaz sharpening routine with images produced using a lens with Smooth Trans Focus lenses? I am just starting to experiment with the Laowa 105mm f/2 T3.2 but imagine more people out there will have the Sony 100 f/2.8 T5.6. In particular I am concerned with the software identifying the boundaries between in and out of focus regions and affecting the edge transitions. I have tried so few images so far that I can not say there is or is no problem but was just wondering if this had come up in the past.