Thanks for your constructive and helpful comments Aldon, but I was having same issue. deNoise works fine. I had sharpen up and working alone, but after trying the plug in and it worked once then failed on the second try, then when i tried to load topaz sharpen directly with lrc closed , that failed as well. So, I uninstalled and reinstalled sharpen, deleted my old lrc preset, made a new one and it seems to be working now. It did two separate images (one sharpen the denoise, one de noise then sharpen) so it seems to be working. Somehow the sharpen program got corrupted during all this the first time around so your preset may be correct, but the program just isn’t loading by any means. Something to check.