Versions of Photo AI after 2.1.0 won’t run in Photoshop if PS is set to open in Rosetta on a Mac. I’ve been in contact with Topaz customer service but thought I would add the issue here (so hopefully it will get fixed soon).
The reason for opening PS in Rosetta is to allow for some older plug-ins to be used. Photo AI 2.1.0 works fine with it; the newer versions cause AI to crash.