No Topaz software opens?

I usually have Adjust AI, Gigapixel and Mask AI installed. Until just recently (not sure when) I’ve had no issues with any of them, but for some reason none of them will open any more. The process appears in task manager but never loads up properly.

I’ve tried reinstalling, running in compatibility modes, updating GPU drivers, completely deleting every reference to Topaz in my registry and user data folders, even installing to a different hard-drive. Nothing has worked.

The only recent change I’ve made to my system is replacing a dead HDD with a new one, but that shouldn’t make the software completely stop working, right?

I don’t think system specs are super relevant, but here they are.