Milkyway Images look extremely blotchy


I have tried to use topaz denoise and the images look very blotchy. It is a Milkyway image shot at ISO 4000. While trying to reduce the noise, the program either doesn’t recognize the noise and makes it more noticeable or just makes the overall image very blotchy. Any suggestions? I have attached an image of the four example renders with this message.

Thank in advance for any support!