Is there a difference between doubling the frame rate (to slow down in premiere later), vs just slowing down by 2X?

Hi folks - I’m loving Topaz Video AI, but I wondered if there is any difference in the process (or more importantly the results) between asking topaz to slow my footage by half, vs just doubling it’s framerate and then slowing it down myself in Premiere.

I understand there may be different use cases for each option, but assuming all that was required was slowed down footage, would there be any visible difference between these two approaches?

Sorry if the question has been asked a million times!!