Guide for optimizing performance for your specific computer?

Has anyone devised a guide for maximizing peak performance (with an emphasis on quality) based on GPU (obviously), CPU cores/CPU type and memory?

you mean optimizing without buying or replacing new hardware?
I don’t think there is a much head room to play with in Topaz.

What I mean is settings to take advantage of your computer hardware for optimal results.

I have pretty much the best GPU, so: what settings also make best use of the type of memory I have and the number of cores and/or the type of CPU that I have.

With 3 layers of enhancement 576p to 1152p

My 2990WX is 18% loaded
My 4x8GB 3200 quad channels is 28 % loaded